OSAplex MK-7

• Egg Free
• Fish Free
• Dairy Free
• Yeast Free
• Wheat Free
• Gluten Free
• Shellfish Free
• Peanuts Free
• Tree Nuts Free
• Soy Protein Free
• Made In Canada
• Vitamin/mineral supplement
• Helps to prevent vitamin D deficiency
• A factor in the maintenance of good health
• Helps in the absorption and use of calcium and phosphorus
• Helps in the development and maintenance of bones and teeth
• Ingredients Derived From Genetically Modified Organisms (Gmos)
• No Artificial Colors, Artificial Sweeten- Ers, Or Artificial Preservatives
• Calcium intake, when combined with sufficient vitamin D, a healthy diet, and regular exercise, may reduce the risk of osteoporosis

Bone health is dependent on a constant supply of micronutrients for maintenance and repair. Instead of adopting a single-nutrient, unbalanced approach to supplementation, XYMOGEN utilizes an array of complementary, well-researched nutrients in its OSAplex formulas to build and maintain bone over time.

Silicon as Choline-Stabilized Orthosilicic Acid (ch-OSA) OSAplex formulas feature ch-OSA, a patented, stabilized, readily absorbed, bioactive form of silicon called orthosilicic acid. Decades of research suggest that there is a strong, positive association between dietary silicon and bone mineral density (BMD).” The mechanisms of action appear to be silicon’s support of collagen synthesis and stabilization, extracellular matrix mineralization, and connective tissue integrity.12. In cell-line studies, orthosilicic acid has been found to stimulate type I collagen synthesis. Type I collagen is a dense, heavily cross-linked protein that creates an extremely high tensile strength and contributes to bone strength and flexibility. These strong collagen strands are believed to create core-post “binding sites” for calcium and other bone minerals. 16-8) A 12-month, randomized, double-blind, placebo-controlled (RDBPC) trial suggested that supplementing with ch-OSA conferred an additional benefit to a calcium/vitamin D regimen by improving bone formation markers and femoral neck T-scores.

Vitamin D3 Cholecalciferol (vitamin D3) is the form of vitamin D that is endogenously synthesized in skin during exposure to sunlight. Unfortunately, several factors can limit this production including smog, sunblock, and geographic location. For many individuals, exogenous supplementation may be beneficial. Vitamin D plays a role in bone metabolism, BMD, and calcium/ phosphorus status; researchers suggest that vitamin D supplementation may decrease bone turnover and increase BMD. Several randomized placebo- controlled trials with vitamin D and calcium showed significant improvement in maintenance of bone integrity. One randomized, population-based, three-year trial indicated that supplementation with vitamin D (800 IU/d) and calcium (1000 mg/d) had a positive and statistically significant impact on total body bone integrity. A pooled analysis evaluating 11 RDBPC trials concluded that vitamin D supplementation (>800 IU daily) was favorable in maintaining hip and nonvertebral bone integrity in those aged 65 and older.¹² The vitamin D3 in OSAplex Vegan is from an edible lichen source and is vegan-suitable.

Calcium as Microcrystalline Hydroxyapatite Concentrate (MCHC) OSAplex and OSAplex MK-7 contain Ossopan MCHC, a premium, standardized bone extract from New Zealand bovine. This hydroxyapatite matrix comprises calcium, phosphorus, magnesium, bioactive growth factors, type I collagen, amino acids, glycosaminoglycans, and a broad range of essential trace elements. Hydroxyapatite is essentially a mineralized matrix that promotes resistance to compression and can be compared to reinforced concrete. 151 Decades of scientific studies suggest that Ossopan supplementation
fundamentally supports BMD and bone health (13-16) A meta-analysis of six controlled studies suggested that hydroxyapatite was significantly more effective than calcium carbonate in supporting bone structure and BMD.

Menaquinone-7 (MK-7) OSAplex MK-7 contains MK-7, a bioactive, bioavailable form of vitamin K. Vitamin K plays an active role in bone metabolism, calcium utilization, and activation of osteocalcin (the protein needed to bind calcium to the mineral matrix in bone). Vitamin K supports bone integrity by moderating the synthesis of prostaglandin E2 and interleukin-6 by osteoclasts.[19,20]. A three-year study utilizing 180 µg/d of MK-7 concluded that MK-7 significantly improved vitamin K status, supported bone mineral content and BMD, and favorably supported bone strength and integrity in healthy postmenopausal women.

Olive Leaf Extract Bonolive, found in OSAplex Vegan, is a pharmaceutical- grade olive leaf extract that features a unique polyphenol complex. Stem cell research suggested that olive polyphenols are associated with increased osteoblast differentiation, increased extracellular matrix mineralization, and bone maintenance. (22) Research on cultured cells and animals suggested that olive polyphenols exert protective effects on the formation and maintenance of bone. A randomized, double-blind, placebo-controlled clinical study provided strong support for Bonolive supplementation. Results revealed that 250 mg/d of Bonolive, along with routine calcium supplementation, promoted a statistically significant improvement (32% increase) in levels of the bone formation marker osteocalcin over a 12-month period. Furthermore, DEXA scan results suggested that Bonolive supplementation positively supported BMD at the lumbar spine and the femur neck compared to placebo.