Bioclinic – Vitamin K2, D3 and A

Feature Summary

Vitamin K2, D3 and A provides clinically relevant doses of the three fat-soluble vitamins essential to optimal bone health. Although needed for cardiovascular health, blood sugar regulation, immune function, and inflammation control, vitamins A, D, and K2 have complementary physiological bone-related functions, such as modulating gene expression in osteoblasts and carboxylating osteocalcin, an enzyme needed for bone formation.¹ This is exemplified by a reduction in undercarboxylated osteocalcin and an increase in bone mineral density (BMD) in postmenopausal women when vitamin K is added to vitamin D supplementation.^2,3,4

Vitamin D has diverse and significant functions in multiple body systems, and widespread deficiency magnifies these crucial roles.^5,6 Supplementation is associated with a well-established reduction in osteoporotic fracture when taken daily at a clinically relevant dose.^7,8 Correcting a vitamin D deficiency is critical when supplementing with vitamin A, as vitamin A appears to promote bone health if vitamin D levels are adequate.^9,10,11 Additionally, maternal vitamin A levels during pregnancy have been associated with the peak bone mass and bone strength of their children, highlighting the unrecognized importance of vitamin A for lifelong bone health, in parallel to the effect of vitamin D on peak bone mass.^12,13 Vitamin K is now recognized as necessary for the carboxylation of enzymes critical for both bone and blood vessel health.14-18 Indeed, meta-analysis has shown an improvement in vertebral bone mineral density (BMD) and a reduction in fracture among postmenopausal women with osteoporosis, while controlled trial data shows a reduction in the age-related decline in BMD among healthy postmenopausal women.^19,20 The naturally derived MK-7 form in Vitamin K2, D3 and A has a longer half-life than any other form.^21,22