Bioclinic – L-Glutamine

Feature Summary

L-glutamine is the most plentiful amino acid in the body, a Krebs cycle intermediary of particular importance to intestinal and immune cells, and one known to be depleted following strenuous physical activity.¹ L-glutamine supplementation has been shown to prevent an exercise-induced increase in intestinal permeability, by promoting tight junction stability, upregulating anti-inflammatory cytokine production, and suppressing inflammation, notably NF-κB activation.² L-glutamine also stimulates protein synthesis pathways, while inhibiting protein degradation.³

Curcumin has well-established anti-inflammatory effects with multiple molecular targets, including NF-κB, as well as cyclooxygenases and lipoxygenases.^4,5 Curcumin supplementation has been shown to mitigate damage to muscles following exercise, reduce pain due to delayed onset muscle soreness, and enhance the recovery of muscle performance.⁶ Theracurmin specifically has been shown to prevent both an increase in creatine kinase and muscle degradation following eccentric exercise.⁷ Theracurmin has been proven effective for symptom relief and a reduced need for rescue medication among participants with knee osteoarthritis in a prospective clinical trial.⁸ L-glutamine and Theracurmin combined target multiple mechanisms associated with muscle repair and function.