Genestra – HMB Complex

HMB Complex: calcium beta-hydroxy beta-methylbutyrate + glutamine, arginine, and BCAA
• May help support a modest improvement in exercise capacity in individuals with stable cardiovascular diseases
• Enhances muscle strength in previously untrained individuals, in combination with intense resistance training exercise
• Provides essential branched chain amino acids (leucine, isoleucine, valine) involved in protein synthesis
• Provides 500 IU of vitamin D per serving

HMB Complex combines beta-hydroxy beta-methylbutyrate (HMB) with two amino acids (glutamine and arginine) involved in muscle protein synthesis, and three essential branched chain amino acids (BCAA); leucine, isoleucine, and valine. HMB is a leucine metabolite that is naturally formed within the body¹ – a 70 kg person produces an estimated 0.2-0.4 g of HMB per day.² HMB up-regulates protein synthesis in muscle cells, stabilizes the muscle cell membrane, and decreases skeletal muscle protein degradation.^{1, 3-7} When combined with regular exercise training, HMB supplementation helps to increase both lean body mass and muscle strength.^8,9 HMB’s effects on muscle mass may be dependent upon vitamin D status; in elderly participants, supplementation with an HMB/arginine/lycine mixture only improved muscle strength in participants with normal serum vitamin D levels (less than 30 ng/mL).¹⁰

REFERENCES
1. Wilson G, Wilson J, and Manninen A. Nutrition & Metabolism 2008, 5:1
2. Pimentel GD, Rosa JC, Lira FS, Zanchi NE, Ropelle ER, Oyama LM et al. Nutrition & Metabolism; 2011; 8: 11
3. Nissen SL, Abumrad NN.  J Nutr Biochem. 1997;8:300-311
4. Eley HL, Russell ST, Tisdale MJ. Am J Physiol Endocrinol Metab. 2008;295:E1409-E1416
5. Eley HL, Russell ST, Tisdale MJ. Am J Physiol Endocrinol Metab. 2008;295:E1417-E1426
6. Yeh SS, Blackwood K, Schuster MW. J Am Med Dir Assoc. 2008;9:219-236
7. Kornasio R, Riederer I, Butler-Browne G, Mouly V, Uni Z, Halevy O. Biochim Biophys Acta. 2009; 1793: 755-763
8. Stout J, Smith-Ryan A, Fukuda D, Kendall K, Moon J, Hoffman J, Wilson J, Oliver J, and Mustad V. Experimental Gerontology. 2013; 48: 1303-1310
9.  Gallagher P, Carrithers J, Godard M, Schulze K, and Trappe S. Medicine & Science in Sports & Exercise. 2000; 32(12): 2109-2115
10. Fuller J, Baier S, Flakoll P, Nissen S, Abumrad N, and Rathmacher J. Journal of Parenteral and Enteral Nutrition, 2011; 35(6): 757-762

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