Genestra – Allisyn

Garlic bulb and cinnamon bark combination
• Used in Herbal Medicine to help maintain cardiovascular health and reduce elevated blood lipid levels in adults
• Provides 10 mg of allicin per daily dose
• Includes 80 mg of cinnamaldehyde per daily dose

Allisyn is a blend of allicyn and cinnamaldehyde that is traditionally used to help support cardiovascular health. The main bioactive compound in garlic is allicin.¹ When broken down, this sulfur containing compound is responsible for the characteristic odor of garlic.¹ Recent research indicates that long term garlic consumption may be effective at decreasing total cholesterol levels in individuals with higher baseline values.¹ Garlic helps to decrease elevated lipid levels by inhibiting cholesterol synthesis and LDL oxidation in the liver.¹ In a randomized, placebo-controlled trial involving 150 hyperlipidemic adults, daily supplementation with 800 mg of garlic powder capsules (providing 2 mg of allicin) for six weeks significantly decreased total and LDL cholesterol by approximately 12 and 17%, respectively.² Similarly, in vitro research demonstrates that cinnamaldehyde decreases mRNA levels of PPAR-γ and SREBP1, transcription factors that regulate lipid synthesis and storage.³ Both cinnamaldehyde and garlic help maintain endothelial cell function by decreasing lipid peroxidation and by inhibiting the pro-inflammatory activities of the transcription factor NFκB.^4,5

REFERENCES
1. Qidwai, W, Ashfaq, T. Evidence-Based Complementary and Alternative Medicine. 2013; 2013: 125649.
2. Kojuri, J, Vosoughi, AR, Akrami, M. Lipids in Health and Disease. 2007; 6:5.
3. Huang, B, Yuan, HD, Kim, DY, Quan, HY, Chung, SH. J. Agric. Food Chem. 2011; 59: 3666_3673.
4. Gruenwald, J, Freder, J, Armbruester, N. Critical Reviews in Food Science and Nutrition. 2010; 50(9): 822-834.
5. Ginter, E, Simko, V. Garlic (Allium sativum L.) and cardiovascular diseases. Bratisl Lek Listy. 2010; 111(8): 452-456.

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