- Provides the natural and most bioactive form of folate, Quatrefolic folate (6S)-5-MTHF, with no synthetic or racemic components
- Quatrefolic folate supplementation has a greater increase in plasma folate compared to folic acid and calcium 5-MTHF
- Contains most bioactive and bioavailable forms of each B vitamin, including methylcobalamin (B12), riboflavin 5’-phosphate (B2), and pyridoxal 5’-phosphate (B6)
- Broad-spectrum B complex, with inositol, biotin, and choline
- Suitable for vegetarians/vegans
Active B Complex provides the most biologically active forms and clinically relevant doses of a unique B vitamin combination. Quatrefolic folate provides (6S)-5-methyltetrahydrofolic acid (MTHF), the active form of folate at the cellular level, which is found in circulation and is the only form able to cross the blood brain barrier. This form of folate bypasses enzymatic conversion by methylene tetrahydrofolate reductase (MTHFR), an enzyme with common genetic polymorphisms known to impair activity. Quatrefolic acid administration has been associated with higher peak (6S)-5-MTHF levels than both folic acid and calcium 5-MTHF, with higher plasma folate levels even in those with high functioning MTHFR polymorphisms. It also shows a more rapid repletion of folate levels among pregnant women than folic acid, along with the ability to lower homocysteine without masking a B12 deficiency.1–4
In addition to superior folate bioavailability, Active B Complex contains superior forms of each B vitamin. Benfotiamine is a lipid-soluble form of vitamin B1 with higher bioavailability than thiamine. It is used in the treatment of diabetic neuropathy because it blocks several hyperglycemic pathways and prevents endothelial dysfunction.5–7 Riboflavin 5’-phospate and pyridoxal 5’-phosphate (PLP) are biologically active forms of B2 and B6. PLP is the most important member of the B6 group and is the active coenzyme for more than 100 enzymes, bypassing hepatic conversion to an active form.8 Active B Complex also provides clinically relevant doses of methylcobalamin, niacin, pantothenic acid, biotin, choline, and inositol.
|Each Vegetarian Capsule Contains:|
|Vitamin B1 (Thiamine Hydrochloride, Benfotiamine)||31.69 mg|
|Vitamin B2 (Riboflavin 5’-Phosphate Sodium)||10 mg|
|Niacin (Inositol Hexanicotinate)||100 mg|
|Pantothenic Acid (Calcium d-Pantothenate)||100 mg|
|Vitamin B6 (Pyridoxal 5’-Phosphate)||25 mg|
|Vitamin B12 (Methylcobalamin)||500 mcg|
|Folate (from (6S)-5-Methyltetrahydrofolic Acid (MTHF), Glucosamine Salt, Quatrefolic®)||400 mcg|
|Choline (Citrate)||50 mg|
|Inositol (Inositol, Inositol Hexanicotinate)||50 mg|
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica, organic kale, organic alfalfa, organic cilantro leaf, organic parsley, caperberry, sprouted garlic, organic artichoke, organic black radish, organic dandelion, barley grass, pepper, organic celery seed, organic beetroot, organic tomato, wasabi rhizome, fresh freeze-dried sprouted broccoli, organic upland cress, daikon, red radish, organic cauliflower, organic cabbage, organic arugula, organic watercress leaf, grape, pomegranate, strawberry, organic cranberry, organic blueberry, raspberry, bilberry, organic Indian gooseberry, schizandra berry, red orange, organic acai berry, Theracurmin® curcumin, organic decaffeinated green tea extract, organic ginger rhizome, organic echinacea, organic oregano, organic peppermint, organic spearmint, organic spirulina, organic chlorella, red algae, blue green algae, kelp.
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for vegetarians/vegans.
1 capsule per day with food or as directed by a health care practitioner.
No reports exist for neuropathies associated with pyridoxal 5’-phosphate, though doses of pyridoxine at 1-3 g per day have been associated with peripheral neuropathy when used in isolation.9 People sensitive to nicotinic acid may experience flushing of the skin that is generally mild and transient.
Although several classes of drugs are known to either interfere with B12 absorption or function, such as aminoglycosides, anticonvulsants, bile acid sequestrants, proton pump inhibitors, antihyperglycemic medications (Metformin), and acne therapy (isotretinoin), there are no known negative interactions caused by B12 supplementation with any medications.10–13 Metformin has been shown to deplete B12 and folate, and supplementation with B12 only in diabetics may be preferable.14
1. Miraglia, N., Agostinetto, M., Bianchi, D., et al. (2016). Enhanced oral bioavailability of a novel folate salt: comparison with folic acid and a calcium folate salt in a pharmacokinetic study in rats. Minerva Ginecol, 68(2), 99-105.
2. Prinz-Langenohl, R., Brämswig, S., Tobolski, O., et al. (2009). [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol, 158(8), 2014-21.
3. Bailey, S. W., &Ayling, J. E. (2018). The pharmacokinetic advantage of 5-methyltetrahydrofolate for minimization of the risk for birth defects. Sci Rep, 8(1), 4096.
4. Sicinska, E., Brzozowska, A., Roszkowski, W., et al. (2018). Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces serum homocysteine concentrations in older adults. Int J Food Sci Nutr, 69(1), 64-73.
5. Schreeb, K. H., Freudenthaler, S., Vormfelde, S. V., et al. (1997). Comparative bioavailability of two vitamin B1 preparations: benfotiamine and thiamine mononitrate (Letter). Eur J Clin Pharmacol, 52, 319-20.
6. Hammes, H. P., Du, X., Edelstein, D., et al. (2003). Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med, 9, 294-9.
7. Stirban, A., Negrean, M., Stratmann, B., et al. (2006). Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Diabetes Care, 29(9), 2064-71.
8. Powers, H. J. (2003). Riboflavin (vitamin B-2) and health. Am J Clin Nutr, 77(6), 1352-60.
9. Head, K. A. (2006). Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev11(4), 294-329.
10. McColl, K. E. (2009). Effect of proton pump inhibitors on vitamins and iron. Am J Gastroenterol, 104(Suppl 2), S5-9.
11. Aslan, K., Bozdemir, H., Unsal, C., et al. (2008). The effect of antiepileptic drugs on vitamin B12 metabolism. Int J Lab Hematol, 30(1), 26-35.
12. Markkanen, T., Salmi, H. A., &Sotaniemi, E. (1965). Effect of neomycin treatment on the vitamin B12 content of human serum and urine. Z Vitam Horm Fermentforsch, 14(1), 66-71.
13. Karadag, A. S., Tutal, E., Ertugrul, D. T., et al. (2011). Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non-controlled study. Int J Dermatol, 50(12), 1564-9.
14. Xu, L., Huang, Z., He, X., et al. (2013). Adverse effect of metformin therapy on serum vitamin B12 and folate: Short-term treatment causes disadvantages? Med Hypotheses, 81(2), 149-51.