Natural Factors Pycnogenol is made from the highest quality French maritime pine bark harvested from natural forests with no pesticides and no herbicides. Pycnogenol is one of the most potent natural antioxidants. Additionally, it is anti-inflammatory, increases nitric oxide levels, and supports collagen and hyaluronic acid production. Pycnogenol can help reduce symptoms of perimenopause and knee osteoarthritis and address age-associated inflammation and free radical damage.