Benefits
- Offers a highly absorbable and bioavailable form of CoQ10
- Increases plasma levels of CoQ10 significantly more per mg compared to ubiquinone
- Allows for higher peak plasma levels of CoQ10, with 200 mg per softgel reflective of clinical trial dosing
- Kaneka Q+ brand for ubiquinol is naturally produced via yeast fermentation and is free of the impurities of synthetically processed CoQ10
- A base of organic flaxseed oil improves solubility and provides ALA-rich omega-3 fatty acids
- Genetically modified organism (GMO) free, allergen free, and Kosher certified
Feature Summary
CoQ10 is commonly called ubiquinone because it is ubiquitous throughout the body and found in nearly every cell. The active form of the molecule, ubiquinol, is a fat-soluble antioxidant that protects fats such as those that make up cellular and mitochondrial membranes, as well as both HDL and LDL cholesterol. However, CoQ10?s most important role is in cellular respiration, the process of generating the energy (ATP) that all cells need for optimal health.1,2,3
Because its role in energy production is so critical, it is particularly important in cells with high energy demands, such as the heart. This helps explain why CoQ10 has shown such significant benefit for conditions affecting the cardiovascular system, such as high blood pressure, cardiomyopathy, protection during cardiac surgery, and protection from statin drugs used to treat high cholesterol. Low levels of CoQ10 have also been reported for many other conditions, with clinical trials supporting the use of CoQ10 for migraine headaches, male infertility, Alzheimer?s (prevention) and Parkinson?s disease (prevention and treatment), and macular degeneration.4,5,6,7,8,9,10 Moderate doses, ranging from 300?600 mg per day, have been used for statin-related myopathy, female infertility (decreased ovarian reserve), and multiple sclerosis.11,12,13
Kaneka Q+ ubiquinol provides the form of CoQ10 found in 95% of human tissues. Higher levels of ubiquinol compared to ubiquinone are a sign of better cellular protection.14 Kaneka Q+ ubiquinol has also been shown to be more soluble than ubiquinone, more effectively increasing blood levels of this nutrient so critical to energy production.15,16,17 A base of organic flaxseed oil improves the solubility of ubiquinol and provides heart-healthy omega-3 fatty acids. Flaxseed oil is especially rich in alpha-linolenic acid, an anti-inflammatory oil associated with improved cardiovascular health.18
Medicinal Ingredients
| Each Softgel Contains: | |
| Ubiquinol (as Kaneka Ubiquinol?) | 200 mg |
| Flaxseed Oil (Linum usitatissimum) (seed) | 340 mg |
Non-Medicinal Ingredients
Softgel (gelatin, glycerin, purified water, carob), yellow beeswax, lecithin (non-GMO), vitamin E (non-GMO sunflower oil).
Allergens:
Contains no artificial colours, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn,egg, fish, shellfish, salt, tree nuts, or GMOs.
Recommended Use:
Recommended Adult Dose: 1 softgel per day or as directed by a health care practitioner.
Contraindications
No significant contraindications.
Drug Interactions
Although existing evidence has not found an interaction, CoQ10 resembles vitamin K structurally, potentially interfering with the anticoagulant warfarin. Close monitoring of the INR is recommended with CoQ10 introduction in these patients. No other negative drug interactions are known for CoQ10, though a number of medications are thought to interfere with CoQ10 synthesis or function in the body, including statin medications, tricyclic antidepressants, and oral hypoglycemic agents.19
- Potgieter, M., Pretorius, E., Pepper, M.S., et al. (2013). Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Nutrition Review, 71(3), 180-188.
- Littarru, G.P., &Tiano, L. (2010). Clinical aspects of coenzyme Q10: an update. Nutrition, 26(3), 250-254.
- Littarru, G.P., &Tiano, L. (2007). Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Molecular Biotechnology, 37(1), 31-37.
- Molyneux, S.L., Florkowski, C.M., George, P.M., et al. (2008). Coenzyme Q10: an independent predictor of mortality in chronic heart failure. Journal of the American College of Cardiology, 52(18), 1435-1441.
- Lei, L., &Liu, Y. (2017). Efficacy of coenzyme Q10 in patients with cardiac failure: a metaanalysis of clinical trials. BMC Cardiovascular Disorders, 17(1), 196.
- Pringshelm, T., Davenport, W., Mackie, G., et al. (2012). Canadian Headache Society guideline for migraine prophylaxis. Canadian Journal of Neurological Sciences, 39(2 Suppl 2), S1-S59.
- Zeng, Z., Li, Y., Lu, S., et al. (2019). Efficacy of CoQ10 as supplementation for migraine: A meta-analysis. Acta Neurologica Scandinavica, 139(3), 284-293.
- Safarinejad, M.R., Safarinejad, S., Shafiei, N., et al. (2012). Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. Journal of Urology, 188(2), 526-531.
- Yoritaka, A., Kawajiri, S., Yamamoto, Y., et al. (2015). Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson?s disease. Parkinsonism & Related Disorders, 21(8), 911-916.
- Littarru, G.P., Tiano, L., Belardinelli, R., et al. (2011). Coenzyme Q (10), endothelial function and cardiovascular disease. Biofactors, 37(5), 366-373.
- Qu, H., Guo, M., Chai, H., et al. (2018). Effects of coenzyme Q10 on statin-induced myopathy: An updated meta-analysis of randomized controlled trials. Journal of the American Heart Association, 7(19), e009835.
- Xu, Y., Nisenblat, V., Lu, C., et al. (2018). Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reproductive Biology and Endocrinology, 16(1), 29.
- Sanoobar, M., Eghtesadi, S., Azimi, A., et al. (2015). Coenzyme Q10 supplementation ameliorates inflammatory markers in patients with multiple sclerosis: a double blind, placebo, controlled randomized clinical trial. Nutritional Neuroscience, 18(4), 169-176.
- Claessens, A.J., Yeung, C.K., Risler, L.J., et al. (2016). Rapid and sensitive analysis of reduced and oxidized coenzyme Q10 in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and application to studies in healthy human subjects. Annals of Clinical Biochemistry, 3(Pt 2), 265-273.
- Langsjoen, P.H., &Langsjoen, A.M. (2014). Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clinical Pharmacology in Drug Devevelopment, 3(1), 13-17.
- Failla, M.L., Chitchumroonchokchai, C., &Aoki, F. (2014). Increased bioavailability of ubiquinol compared to that of ubiquinone is due to more efficient micellarization during digestion and greater GSH-dependent uptake and basolateralsSecretion by Caco-2 Cells. Journal of Agricultural and Food Chemistry, 62(29), 7174-7182.
- Zhang, Y., Liu, J., Chen, X.Q., et al. (2018). Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food &Function, 9(11), 5653-5659.
- Parikh, M., Maddaford, T.G., Austria, J.A., et al. (2019). Dietary flaxseed as a strategy for improving human health. Nutrients, 11(5), 1171.
- Bonakdar, R.A., &Guarneri, E. (2005). Coenzyme Q10. American Family Physician, 72(6), 1065-1070.
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Brand
Bioclinic Naturals
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